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Cat No. | Product Name | Synonyms | Targets |
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T76910 | Astegolimab | RG 6149,MSTT 1041A | Interleukin |
Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe ast... | |||
T77045 | Itepekimab | REGN-3500,SAR-440340 | Others |
Itepekimab (REGN-3500) is a potent monoclonal antibody against IL-33.Itepekimab reduces airway inflammation and associated tissue damage in in vivo experiments and can be used to study asthma. | |||
T76679 | Etokimab | ||
Etokimab (Antibody ANB 020), a humanized monoclonal antibody, specifically targets IL-33. It is utilized in the research of atopic dermatitis [1]. | |||
T83741 | S7 TFA | Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH | |
S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 µM, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPM... | |||
T73149 | HPK1-IN-33 | ||
HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cel... | |||
T29542 | AC708 | AC 708,AC-708 | |
AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells culture... | |||
T69671 | SR1903 TFA | ||
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec... | |||
T35638 | SR 1903 | ||
SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al... | |||
T37052 | Tetranactin | ||
Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold g... |
Cat No. | Product Name | Species | Expression System |
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TMPJ-01210 | IL-33 Protein, Mouse, Recombinant | Mouse | E. coli |
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi... | |||
TMPY-05449 | IL-33 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
IL-33 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.1 kDa and the accession number is A0A2K5W3I1. | |||
TMPY-02789 | IL-33 Protein, Canine, Recombinant | Canine | E. coli |
IL-33 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.8 kDa and the accession number is O97863. | |||
TMPY-00861 | IL-33 Protein, Human, Recombinant | Human | E. coli |
IL-33 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is O95760-1. | |||
TMPJ-00617 | IL-33 Protein, Rhesus macaque, Recombinant (His) | Rhesus | E. coli |
Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the pr... | |||
TMPK-00163 | IL-33 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are exp... | |||
TMPH-03115 | IL-33 Protein, Pig, Recombinant (GST) | Sus scrofa (Pig) | E. coli |
N/A. IL-33 Protein, Pig, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 44.6 kDa and the accession number is M5B263. | |||
TMPK-00405 | IL-17RA Protein, Human, Recombinant (aa 33-320, hFc & Avi), Biotinylated | Human | HEK293 Cells |
Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restr... | |||
TMPK-01029 | IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His) | Mouse | HEK293 Cells |
Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disea... | |||
TMPK-01202 | CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated | Human | HEK293 Cells |
CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperrespons... | |||
TMPJ-01361 | Siglec-8 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory mo... |